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Spinal Cord Atrophy and Disability in MS Neurol 51:234-238, Stevenson,V.L.,et al, 1998 See this aricle in Pubmed Article Abstract This study confirms that patient have significantly smaller cords than control subjects at baseline and demonstrated that patients have a significant loss in cord cross-sectional area during 12 months,which was not seen in control subjects.This reduction in cord size was most marked in the primary progressive patients who had a mean cord cross-sectional area loss of 3.52 mm2 and least in the secondary progressive.The baseline cord cross-sectional area correlated strongly with the EDSS and with the disease duration however,there was no significant difference in the cord area or change in cord area between those patients with a definite increase in EDSS and those without.This study demonstrates,for the first time,that it is possible to measure changes in cord cross-sectional area over time.The serial measurement of spinal cord atrophy may thus make an important contribution to the evaluation of therapeutic efficacy, especially in primary progressive disease.

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